Classic PAN is characterized by what type of transmural inflammation?

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Prepare for the CVP and GI Pathology Exam with our quiz. Study with interactive flashcards and challenging multiple choice questions. Each question comes with explanations and hints. Boost your confidence and knowledge!

Multiple Choice

Classic PAN is characterized by what type of transmural inflammation?

Explanation:
Classic polyarteritis nodosa shows inflammation that goes through the full thickness of the vessel wall (transmural) but occurs in discrete segments with unaffected portions in between—that patchy, segmental pattern is the hallmark. This segmental involvement creates skip lesions and is contrasted with a diffuse or uniform involvement of the vessel. Histologically, you often see transmural necrotizing inflammation with fibrinoid necrosis of the media, sometimes with aneurysm formation in the affected arteries.

Classic polyarteritis nodosa shows inflammation that goes through the full thickness of the vessel wall (transmural) but occurs in discrete segments with unaffected portions in between—that patchy, segmental pattern is the hallmark. This segmental involvement creates skip lesions and is contrasted with a diffuse or uniform involvement of the vessel. Histologically, you often see transmural necrotizing inflammation with fibrinoid necrosis of the media, sometimes with aneurysm formation in the affected arteries.

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