Factor IX is decreased in which hemophilia?

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Multiple Choice

Factor IX is decreased in which hemophilia?

Explanation:
Understanding that each hemophilia is defined by a specific coagulation factor that is deficient helps you map the disease to the factor. Hemophilia B arises from a deficiency of factor IX (the Christmas factor), so the factor that is decreased in this hemophilia is factor IX. Clinically, this presents with a prolonged activated partial thromboplastin time (aPTT) and a normal prothrombin time (PT), and a low factor IX activity confirms the diagnosis. By comparison, Hemophilia A is due to factor VIII deficiency, while deficiencies of factor X or factor II are not the classic hemophilia conditions described by this naming scheme.

Understanding that each hemophilia is defined by a specific coagulation factor that is deficient helps you map the disease to the factor. Hemophilia B arises from a deficiency of factor IX (the Christmas factor), so the factor that is decreased in this hemophilia is factor IX. Clinically, this presents with a prolonged activated partial thromboplastin time (aPTT) and a normal prothrombin time (PT), and a low factor IX activity confirms the diagnosis. By comparison, Hemophilia A is due to factor VIII deficiency, while deficiencies of factor X or factor II are not the classic hemophilia conditions described by this naming scheme.

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