Folate deficiency anemia is the same as B12 deficiency but lacks involvement of which system?

Folate deficiency anemia is the same as B12 deficiency but lacks involvement of which system?

• A. Cardiovascular
• B. Neurologic
• C. Gastrointestinal
• D. Hematologic

Answer: (B)

Both folate and B12 deficiencies cause megaloblastic anemia because they impair DNA synthesis in rapidly dividing cells. The crucial difference is neurologic involvement: B12 deficiency disrupts myelin synthesis, leading to neurologic symptoms such as neuropathy and gait disturbances. Folate deficiency does not cause these neurologic changes. So the system not involved in folate deficiency, compared with B12 deficiency, is the neurologic system.

Both folate and B12 deficiencies cause megaloblastic anemia because they impair DNA synthesis in rapidly dividing cells. The crucial difference is neurologic involvement: B12 deficiency disrupts myelin synthesis, leading to neurologic symptoms such as neuropathy and gait disturbances. Folate deficiency does not cause these neurologic changes. So the system not involved in folate deficiency, compared with B12 deficiency, is the neurologic system.