True or false: Angiosarcoma can be induced by radiation.

True or false: Angiosarcoma can be induced by radiation.

• A. False
• B. True
• C. Not established
• D. Rare

Answer: (B)

Radiation exposure can trigger malignant transformation of endothelial cells, so angiosarcoma can arise in tissues that have been irradiated. This is a recognized pattern for radiation-associated sarcomas: after therapeutic radiotherapy, especially in the skin/soft tissue of the irradiated field, angiosarcoma may develop years later (often with a latency of several years). The tumor comes from endothelial cells, so it commonly stains for vascular markers such as CD31 and ERG on immunohistochemistry. Clinically it may look like a bruised or rapidly enlarging lesion in the irradiated area and tends to be aggressive, with a high risk of local recurrence and metastasis. Treatment centers on wide surgical excision with clear margins; past radiotherapy in the same region often complicates management, and response to chemotherapy is variable. In short, radiation can induce angiosarcoma.

Radiation exposure can trigger malignant transformation of endothelial cells, so angiosarcoma can arise in tissues that have been irradiated. This is a recognized pattern for radiation-associated sarcomas: after therapeutic radiotherapy, especially in the skin/soft tissue of the irradiated field, angiosarcoma may develop years later (often with a latency of several years). The tumor comes from endothelial cells, so it commonly stains for vascular markers such as CD31 and ERG on immunohistochemistry. Clinically it may look like a bruised or rapidly enlarging lesion in the irradiated area and tends to be aggressive, with a high risk of local recurrence and metastasis. Treatment centers on wide surgical excision with clear margins; past radiotherapy in the same region often complicates management, and response to chemotherapy is variable. In short, radiation can induce angiosarcoma.