Which of the following is NOT an acquired clotting factor deficiency?

Which of the following is NOT an acquired clotting factor deficiency?

• A. Hemophilia A
• B. Liver Disease
• C. DIC
• D. Vitamin K deficiency

Answer: (A)

The key idea is that some clotting factor deficiencies are inherited, while others are acquired from an illness or nutritional issue. Hemophilia A is an inherited deficiency of factor VIII due to a mutation in the F8 gene and is typically passed down in families (X‑linked recessive). Because it’s congenital, it’s not caused by factors like liver injury, vitamin K deficiency, or a consumption coagulopathy, which are the classic examples of acquired deficiencies. In contrast, vitamin K deficiency lowers the vitamin K–dependent factors (II, VII, IX, X); liver disease reduces synthesis of several clotting factors; and DIC consumes clotting factors, all representing acquired problems. Since Hemophilia A is caused by a genetic defect present from birth rather than a result of an acquired condition, it is the NOT acquired deficiency.

The key idea is that some clotting factor deficiencies are inherited, while others are acquired from an illness or nutritional issue. Hemophilia A is an inherited deficiency of factor VIII due to a mutation in the F8 gene and is typically passed down in families (X‑linked recessive). Because it’s congenital, it’s not caused by factors like liver injury, vitamin K deficiency, or a consumption coagulopathy, which are the classic examples of acquired deficiencies. In contrast, vitamin K deficiency lowers the vitamin K–dependent factors (II, VII, IX, X); liver disease reduces synthesis of several clotting factors; and DIC consumes clotting factors, all representing acquired problems. Since Hemophilia A is caused by a genetic defect present from birth rather than a result of an acquired condition, it is the NOT acquired deficiency.